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This area of the problem regulates reward responses in establishing food and sex, plus nurturing infants and children. One of the most important neurotransmitters involved in reward responses, both after they malfunction and once they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the quantity of dopamine released in in response to a stimulus"(Bostwick & Bucci, 2008). Using two separate drugs to lose weight can be very effective you will find combinations in front of the FDA now awaiting approval. When dealing with weight-loss and the people that go through it you ought to err to the side of caution and allow the FDA do its job and demand some research be done so the public is aware of the side effects and hazards of the medications before we drive them. Keep in mind that drug companies will be in business to generate income and that they would say anything to keep people on the medications. Researchers discovered that participants investing in this drug to get a year, lost excess weight within one month and have kept the extra weight off during the entire 56 weeks in the study. Contrave is often a combination in the drugs naltrexone and bupropion, which seems to reflect a new trend of weight-loss drugs which can be made up of many active ingredient, which might make them more efficient and safer. Combo-pilling could be the newest fad or even better the newest to come under scrutiny and thus it is just more publicly known although in the past, comb-pilling for weight reduction has been around since the eighties. The biggest reason that using a combination of pills is now popular could be the fact that by right now there aren't any long term prescription diet pills that have been licensed by the FDA besides orlistat. The truly disturbing part is doctors are prescribing these combinations of medications even though some of the combinations are already rejected or have yet to be authorized by the FDA. Seizures certainly are a side effect with Contrave and really should not be taken in people with seizure disorders. The drug could also raise blood pressure levels and heartbeat, and really should not be used in people who have a history of cardiac event or stroke in the earlier six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy with the drug. The FDA also warned that Contrave can raise blood pressure levels and heartbeat and must not used in patients with uncontrolled high blood pressure levels, along with by a person with heart-related and cerebrovascular (circulation dysfunction impacting the mind) disease. Patients using a history of cardiac arrest or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes having a boxed warning to alert physicians and patients to the increased chance of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stop smoking. From a psychiatric point of view, evidence implies that the ordinary neural mechanism for goal-directed behavior continues to be hijacked by the addiction, and malfunctions in a way that its ordinary functions are exaggerated and fixated on its object. An object creates a stimulus and also the person engages in a "goal-directed behavioral response" that creates a "natural high"(Bostwick & Bucci, 2008).